LibreOffice offers 12 standard layouts, as can be seen below:
Not all of these layouts are suitable to present plots, but for those who are, the dimensions of the layout boxes should be taken into account to create legible plots. E.g. in Matplotlib this can be accomplished with the following command:
matplotlib.rc('figure', figsize= [width,height])
Moreover, it is advantageous to modify some other style options to make a plot more legible. Some style options which I found helpful in the past are the following:
matplotlib.rc('lines', linewidth=4.0) #thick lines
matplotlib.rc('font', size=18) #big font
matplotlib.rcParams.update({'font.sans-serif': 'Liberation Sans'}) #adjust font w/ slide font
In my opinion .png is one of the few trustworthy output formats for plots. Generally producing plots in vector formats (e.g. .svg) would be nicer, but at least I have experienced these being rendered incorrectly (LibreOffice 4.3.6.2 was used at the time of this writing).
An example slide with these style options applied is shown below:
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